Tritium Labeling of p-Aminosalicylic Acid (PAS).

Para-Aminosalicylic Acid: Pas

Improved specificity of the PABA test with p-aminosalicylic acid (PAS).

Until now use of the PABA test together with [14C] PABA to calculate the PABA excretion index has probably been the best adaptation suggested to enhance the specificity of this non-invasive pancreatic function test. Drawbacks of the method are the application of radioactivity, the fact that children, pregnant women, and patients with renal insufficiency have to be excluded from the test, and th...

Serum concentrations of para-aminosalicylic acid (PAS) produced by various forms of PAS.

Para-aminosalicylic acid (PAS) is now generally accepted as an effective antibacterial agent in the treatment of certain forms of tuberculosis when administered alone or in combination with one of the streptomycins. However, there remains a great deal of uncertainty as to the best method of administering the drug. Both the free acid and the sodium salt of PAS have been given in various dosage f...

Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague-Dawley rats.

Para-aminosalicylic acid (PAS), an FDA-approved anti-tuberculosis drug, has been used successfully in the treatment of severe manganese (Mn)-induced Parkinsonism in humans [Jiang Y-M, Mo X-A, Du FQ, Fu X, Zhu X-Y, Gao H-Y, et al. Effective treatment of manganese-induced occupational Parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study. J Occup Environ Med 2006;48:644-9]. T...

Mechanism of competitive inhibition of p-aminobenzoic acid oxidation by p-aminosalicylic acid.

The proposed mechanism(s) associated with the inhibition of essential metabolic reactions by various compounds has received a great deal of attention in recent years, since antimetabolites have proved useful in several chemotherapeutic areas and in studying various metabolic reactions. The significance of p-aminobenzoic acid in microbial nutrition was first emphasized when Woods (1940) and Wood...